Effects of Non-invasive, 1210 nm Laser Exposure on Fat

Side Effects, Complications of Various Lasers, Light Devices

Effects of Non-invasive, 1210 nm Laser Exposure on Fat

PostPosted by DCNGA » Tue Sep 21, 2010 6:16 pm

From 2009:

http://www.ncbi.nlm.nih.gov/pubmed/19588533

Lasers Surg Med. 2009 Aug;41(6):401-7.

Effects of non-invasive, 1,210 nm laser exposure on adipose tissue: results of a human pilot study.
Wanner M, Avram M, Gagnon D, Mihm MC Jr, Zurakowski D, Watanabe K, Tannous Z, Anderson RR, Manstein D.

Department of Dermatology, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Abstract
BACKGROUND AND OBJECTIVES: Laser radiation (1,210 nm) has been previously shown to be capable of selective photothermolysis of adipose tissue in vitro when applied non-invasively. The objective of this pilot study was to evaluate the in vivo effects of this laser in human subjects.

STUDY DESIGN/MATERIALS AND METHODS: Twenty-four adult subjects were exposed non-invasively on the abdomen to a 1,210 nm laser at fluences of 70, 80, and 90 J/cm(2), with a 10 mm spot size, 5 seconds pre-cooling, and 3 seconds exposure duration delivered with parallel contact cooling. There was an impairment of the skin-cooling device during the study. Exposure and control sites were biopsied at either 1-3 days or 4-7 weeks. Tissue was processed for nitroblue tetrazolium chloride (NBTC) staining, a marker for thermal damage, and hematoxylin and eosin (H&E) staining.

RESULTS: Laser exposures were painful, requiring local anesthesia in most subjects, but otherwise well tolerated. At 1-3 days after exposure, there was a fluence-dependent loss of NBTC staining in the fat and dermis. In 2 of 14 subjects (2 of 42 exposure sites) evaluated at 1-3 days after exposure, epidermal damage was noted within a small portion of the test site, likely due to impaired contact cooling. At 4-7 weeks, lipomembranous changes of the fat were seen in 89% of test sites and 33% of control sites.

CONCLUSIONS: This in vivo study shows histologic evidence of laser-induced damage of fat. With further development, this might become a useful treatment for disorders involving the fat and/or lower dermis.

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Re: Effects of Non-invasive, 1210 nm Laser Exposure on Fat

PostPosted by DCNGA » Wed Sep 22, 2010 1:07 pm

Please note that Rox Anderson, one of the authors of this 'research' study invented the technology that spawned Zeltiq from this 'research' Dr. Anderson is a Mass Gen doc and a leading laser doc. Zeltiq is poised to be the next great 'fat melting' laser and will make millions for the device maker and the inventors of this device.

Dr. Rox Anderson, a dermatologist at Massachusetts General Hospital who is credited with inventing the technology behind Zeltiq, said he first tried lasers to melt fat cells — but it hurts when your fat is being cooked.


Dr. Mathew M. Avram, another Mass. General dermatologist, who consults for and owns stock in Zeltiq, said he thinks the body contouring procedures are part of a larger trend in aesthetic treatments.


Cryolipolysis(TM), the science behind the Zeltiq Procedure, was discovered by dermatologists Dieter Manstein, MD, and R. Rox Anderson, MD, of the Wellman Center for Photomedicine at Massachusetts General Hospital, affiliated with Harvard Medical School in Boston, Mass.


Zeltiq conducted the first human study to test the safety and efficacy of its device for fat layer reduction of love handles and back fat pads in men and women. The unique bilateral control study design showed unequivocal results at relatively low energy settings with an early clinical prototype device. Based on ultrasound assessment, an average fat layer reduction of 22.4% was demonstrated after only one procedure.

"It is a good thing to learn caution from the misfortunes of others."

"If you wish to succeed in life, make perseverance your bosom friend, experience your wise counselor, caution your elder brother, and hope your guardian genius."
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