Systemic Responses to Burn Injury

Side Effects, Complications of Various Lasers, Light Devices

Systemic Responses to Burn Injury

PostPosted by WG1 » Mon Feb 06, 2012 1:20 pm

http://journals.tubitak.gov.tr/medical/issues/sag-04-34-4/sag-34-4-1-0405-1.pdf

The local and systemic inflammatory response to
thermal injury is extremely complex, resulting in both
local burn tissue damage and deleterious systemic effects
on all other organ systems distant from the burn area
itself.


Immune Response
Severe thermal injury induces an immunosuppressed
state that predisposes patients to subsequent sepsis and
multiple organ failure, which are the major causes of
morbidity and mortality in burn patients (73,74). A
growing body of evidence suggests that the activation of
a pro-inflammatory cascade after burn injury is
responsible for the development of immune dysfunction,
susceptibility to sepsis, and multiple organ failure (75).
Moreover, thermal injury increases the macrophage
activity, thereby increasing the productive capacity for the
pro-inflammatory mediators (76). There have been
several reports indicating that circulating levels of IL-1b,
IL-6 and TNF-a are increased in patients with burn injury
WG1
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Re: Systemic Responses to Burn Injury

PostPosted by WG1 » Mon Feb 06, 2012 1:25 pm

I haven't read the whole thing. I keep trying but I'm so busy. What do you all think? Since the epidermal injury is minimal, the sepsis and microbes issues will likely not apply in most cases.

I need time to read this article uninterrupted.
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