From 2006: http://www.skinandaging.com/supplements ... ersies.pdf
Could Some People be Non-Responders?
Could there be one or more temperature dependent variants in collagen and/or elastic tissue or a temperature-dependent variable in the systems responsible for the production of cytokines and other variables such as heat shock proteins such that some individuals respond well to a given thermal load administered in a standard, non-ablative treatment? Or, could apparently similar individuals have protein structures or other biological subsystems that are relatively thermal-stable with the range of thermal loads imposed during typical non-ablative treatment and so they’re poor responders?
Could there be some individuals whose recurrent regenerative processes are called into action by a moderate thermal insult of the type that we ordinarily give, while other, similar-appearing people are thermal-stable or even thermal-resistant or are thermophiles and are condemned to existence as non-responders? If the above speculations prove to be clinically relevant, perhaps some day we will have a set of genetic probes or other markers.