From 2011: http://onlinelibrary.wiley.com/doi/10.1 ... 230.x/full
Formation of Fibrosis After Nonablative and Ablative Fractional Laser Therapy
Bas S. Wind MD, PhD1,2,*, Arne A. Meesters MSc1, Marije W. Kroon MD1,2, Johan F. Beek MD, PhD3, J.P. Wietze van der Veen MD, PhD1,2,5, Allard C. van der Wal MD, PhD4, Jan D. Bos MD, PhD2, Albert Wolkerstorfer MD, PhD1,2Article first published online: 28 NOV 2011
Fractional laser therapy (FLT) has become a widely accepted modality for skin rejuvenation and has also been used in various other skin diseases.
To observe long-term histologic effects of nonablative and ablative FLT in the treatment of pigment disorders.
A randomized controlled observer-blinded study was performed in 18 patients with pigment disorders. Two similar test regions were randomized to receive FLT with intermittent topical bleaching or topical bleaching alone. Patients with ashy dermatosis (AD) and postinflammatory hyperpigmentation (PIH) were treated using nonablative 1,550-nm FLT (15 mJ/microbeam, 14–20% coverage), whereas patients with Becker's nevus (BN) were treated with ablative 10,600-nm FLT (10 mJ/microbeam, 35–45% coverage) for three to five sessions. Biopsies were obtained 3 months after the last treatment.
At follow-up, dermal fibrosis was observed in four of eight patients treated using ablative FLT and no patients treated using nonablative FLT (p < .05).
Assuming that the dermal response is comparable in AD, PIH, and BN, at the given settings, ablative FLT may induce fibrosis, whereas treatment with nonablative FLT does not. Whether formation of fibrosis has to be regarded as dermal remodeling or a subtle subclinical form of scarring should be investigated in future research.
What is fibrosis?
Fibrosis is a process that follows chronic inflammation. Fibrotic tissue is like a scar tissue, thick, and rigid, due to excess accumulation of protein below the skin.
The Fraxel Re:pair laser (Solta Medical, Inc.) is an ablative fractionated laser.