Resources on IPL Side Effects, Complications, and Research


PostPosted by DCNGA » Mon Dec 19, 2011 6:03 pm

Contrary to the advertising hype of doctor's and spas's, IPL for wrinkling or tightening is NOT EFFECTIVE according to this study published last month:

From 2011:


Intense pulsed light photorejuvenation: a histological and immunohistochemical evaluation.
El-Domyati M, El-Ammawi TS, Moawad O, Medhat W, Mahoney MG, Uitto J.
SourceDepartment of Dermatology, Al-Minya University, Al-Minya, Egypt. moetazeldomyati@yahoo.com

BACKGROUND: The use of intense pulsed light (IPL) for facial rejuvenation had been the topic of many studies. However, few of them discussed quantitative changes in extracellular matrix proteins after IPL therapy.

OBJECTIVE: To objectively quantify the histological changes in extracellular matrix proteins after IPL treatment for facial wrinkles.

METHODS: Biopsy specimens were obtained from the periocular area of six volunteers of Fitzpatrick skin type III-IV and Glogau's class I-III wrinkles. They were subjected to three months of IPL treatment (six sessions at two-week intervals). Using histological and immunostaining analysis coupled with computerized morphometric analysis, quantitative evaluation of collagen types I, III and VII, newly synthesized collagen, total elastin and tropoelastin was performed for skin biopsies at baseline, end of treatment, and three months post-treatment.

RESULTS: Clinical assessment of volunteers did not show clinically noticeable improvement in facial wrinkles after IPL treatment. Furthermore, quantitative evaluation of extracellular matrix proteins showed no statistically significant changes (P>0.05) in response to IPL treatment

CONCLUSION: Although 50 percent of volunteers showed mild improvement in skin texture at the end of IPL treatment, none of them reported improvement in skin tightening or wrinkles. No statistically significant histological changes were observed three months post IPL treatment.

"It is a good thing to learn caution from the misfortunes of others."

"If you wish to succeed in life, make perseverance your bosom friend, experience your wise counselor, caution your elder brother, and hope your guardian genius."
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